James Hamilton, 1st Lord Hamilton

James Hamilton, 1st Lord Hamilton of Cadzow (d. 1479) was a Scottish nobleman.

Connected with the house of Douglas by his marriage with the widow of the 5th Earl of Douglas and that of her daughter (the Fair Maid of Galloway) with the 8th Earl. He was created a Lord of Parliament in 1445, accompanied the 8th Earl of Douglas to Rome in 1450 and attended him to his fatal meeting with James II at Stirling in 1452. He joined the 9th Earl of Douglas in renunciation of allegiance and subsequent submission in 1453. He later advised another rebellion, but went over to the King's side owing to Douglas's weakness. He was a Commissioner for peace with England and sheriff of Lanarkshire in 1455. He married Mary Stewart, sister of James III.