Mary Myfanwy Evans was born in London. She married the artist John Piper, with whom she lived in rural surroundings at Fawley Bottom near Henley-on-Thames for much of her life. She collaborated with the composer Benjamin Britten on several of his operas.
Together, John and Myfanwy Piper started an artistic dynasty. The most important was their eldest son, Edward Piper (1938â€"1990). Also son Sebastian Piper (painter and musician), and their grandchildren, Luke Piper (painter) and Henry Piper (sculptor).